Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial.
Identifieur interne : 000879 ( Main/Exploration ); précédent : 000878; suivant : 000880Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial.
Auteurs : Andrew Blauvelt [États-Unis] ; Marjolein De Bruin-Weller [Pays-Bas] ; Melinda Gooderham [Canada] ; Jennifer C. Cather [États-Unis] ; Jamie Weisman [États-Unis] ; David Pariser [États-Unis] ; Eric L. Simpson [États-Unis] ; Kim A. Papp [Canada] ; H Chih-Ho Hong [Canada] ; Diana Rubel [Australie] ; Peter Foley [Australie] ; Errol Prens [Pays-Bas] ; Christopher E M. Griffiths [Royaume-Uni] ; Takafumi Etoh [Japon] ; Pedro Herranz Pinto [Espagne] ; Ramon M. Pujol [Espagne] ; Jacek C. Szepietowski [Pologne] ; Karel Ettler [République tchèque] ; Lajos Kemény [Hongrie] ; Xiaoping Zhu [États-Unis] ; Bolanle Akinlade [États-Unis] ; Thomas Hultsch [États-Unis] ; Vera Mastey [États-Unis] ; Abhijit Gadkari [États-Unis] ; Laurent Eckert [France] ; Nikhil Amin [États-Unis] ; Neil M H. Graham [États-Unis] ; Gianluca Pirozzi [États-Unis] ; Neil Stahl [États-Unis] ; George D. Yancopoulos [États-Unis] ; Brad Shumel [États-Unis]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Antiasthmatiques (usage thérapeutique), Anticorps monoclonaux (usage thérapeutique), Association de médicaments, Eczéma atopique (traitement médicamenteux), Femelle, Hormones corticosurrénaliennes (usage thérapeutique), Humains, Indice de gravité médicale, Injections sous-cutanées, Mâle, Méthode en double aveugle, Résultat thérapeutique, États-Unis d'Amérique.
- MESH :
- traitement médicamenteux : Eczéma atopique.
- usage thérapeutique : Antiasthmatiques, Anticorps monoclonaux, Hormones corticosurrénaliennes.
- Adulte, Association de médicaments, Femelle, Humains, Indice de gravité médicale, Injections sous-cutanées, Mâle, Méthode en double aveugle, Résultat thérapeutique, États-Unis d'Amérique.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Adult, Anti-Asthmatic Agents (therapeutic use), Antibodies, Monoclonal (therapeutic use), Dermatitis, Atopic (drug therapy), Double-Blind Method, Drug Therapy, Combination, Female, Humans, Injections, Subcutaneous, Male, Severity of Illness Index, Treatment Outcome, United States.
- MESH :
- chemical , therapeutic use : Adrenal Cortex Hormones, Anti-Asthmatic Agents, Antibodies, Monoclonal.
- drug therapy : Dermatitis, Atopic.
- Adult, Double-Blind Method, Drug Therapy, Combination, Female, Humans, Injections, Subcutaneous, Male, Severity of Illness Index, Treatment Outcome, United States.
Abstract
Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis. Previous 16-week monotherapy studies showed that dupilumab substantially improved signs and symptoms of moderate-to-severe atopic dermatitis with acceptable safety, validating the crucial role of interleukin 4 and interleukin 13 in atopic dermatitis pathogenesis. We aimed to evaluate the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical corticosteroids in adults with moderate-to-severe atopic dermatitis.
DOI: 10.1016/S0140-6736(17)31191-1
PubMed: 28478972
Affiliations:
- Australie, Canada, Espagne, France, Hongrie, Japon, Pays-Bas, Pologne, Royaume-Uni, République tchèque, États-Unis
- Angleterre, Catalogne, Communauté de Madrid, Grand Manchester, Géorgie (États-Unis), Hollande-Méridionale, Massachusetts, New Jersey, Oregon, Région de Kantō, Texas, Utrecht (province), Victoria (État), Virginie, État de New York
- Barcelone, Madrid, Manchester, Melbourne, Rotterdam, Tokyo, Utrecht
- Université de Manchester, Université de Melbourne
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Le document en format XML
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Papp</name><affiliation wicri:level="1"><nlm:affiliation>K Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>K Papp Clinical Research and Probity Medical Research, Waterloo, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Hong, H Chih Ho" sort="Hong, H Chih Ho" uniqKey="Hong H" first="H Chih-Ho" last="Hong">H Chih-Ho Hong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Skin Science, University of British Columbia, and Probity Medical Research, Surrey, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Dermatology and Skin Science, University of British Columbia, and Probity Medical Research, Surrey, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Rubel, Diana" sort="Rubel, Diana" uniqKey="Rubel D" first="Diana" last="Rubel">Diana Rubel</name><affiliation wicri:level="1"><nlm:affiliation>Australian National University, Canberra, and Probity Medical Research, Phillip, ACT, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian National University, Canberra, and Probity Medical Research, Phillip, ACT</wicri:regionArea><wicri:noRegion>ACT</wicri:noRegion></affiliation></author><author><name sortKey="Foley, Peter" sort="Foley, Peter" uniqKey="Foley P" first="Peter" last="Foley">Peter Foley</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Parkville, Skin & Cancer Foundation Inc, Carlton, and Probity Medical Research, Carlton, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Parkville, Skin & Cancer Foundation Inc, Carlton, and Probity Medical Research, Carlton, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Prens, Errol" sort="Prens, Errol" uniqKey="Prens E" first="Errol" last="Prens">Errol Prens</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus University Medical Center Rotterdam, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Griffiths, Christopher E M" sort="Griffiths, Christopher E M" uniqKey="Griffiths C" first="Christopher E M" last="Griffiths">Christopher E M. Griffiths</name><affiliation wicri:level="4"><nlm:affiliation>The Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Etoh, Takafumi" sort="Etoh, Takafumi" uniqKey="Etoh T" first="Takafumi" last="Etoh">Takafumi Etoh</name><affiliation wicri:level="3"><nlm:affiliation>Tokyo Teishin Postal Services Agency Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Teishin Postal Services Agency Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Pinto, Pedro Herranz" sort="Pinto, Pedro Herranz" uniqKey="Pinto P" first="Pedro Herranz" last="Pinto">Pedro Herranz Pinto</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, La Paz University Hospital, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Dermatology, La Paz University Hospital, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pujol, Ramon M" sort="Pujol, Ramon M" uniqKey="Pujol R" first="Ramon M" last="Pujol">Ramon M. Pujol</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Hospital del Mar, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Dermatology, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Szepietowski, Jacek C" sort="Szepietowski, Jacek C" uniqKey="Szepietowski J" first="Jacek C" last="Szepietowski">Jacek C. Szepietowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Venereology and Allergology, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Dermatology, Venereology and Allergology, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Ettler, Karel" sort="Ettler, Karel" uniqKey="Ettler K" first="Karel" last="Ettler">Karel Ettler</name><affiliation wicri:level="1"><nlm:affiliation>Dermatology and Venereology, Hradec Kralove, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Dermatology and Venereology, Hradec Kralove</wicri:regionArea><wicri:noRegion>Hradec Kralove</wicri:noRegion></affiliation></author><author><name sortKey="Kemeny, Lajos" sort="Kemeny, Lajos" uniqKey="Kemeny L" first="Lajos" last="Kemény">Lajos Kemény</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Dermatology and Allergology, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Xiaoping" sort="Zhu, Xiaoping" uniqKey="Zhu X" first="Xiaoping" last="Zhu">Xiaoping Zhu</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Basking Ridge, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Basking Ridge, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Akinlade, Bolanle" sort="Akinlade, Bolanle" uniqKey="Akinlade B" first="Bolanle" last="Akinlade">Bolanle Akinlade</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hultsch, Thomas" sort="Hultsch, Thomas" uniqKey="Hultsch T" first="Thomas" last="Hultsch">Thomas Hultsch</name><affiliation wicri:level="2"><nlm:affiliation>Sanofi, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sanofi, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mastey, Vera" sort="Mastey, Vera" uniqKey="Mastey V" first="Vera" last="Mastey">Vera Mastey</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gadkari, Abhijit" sort="Gadkari, Abhijit" uniqKey="Gadkari A" first="Abhijit" last="Gadkari">Abhijit Gadkari</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Eckert, Laurent" sort="Eckert, Laurent" uniqKey="Eckert L" first="Laurent" last="Eckert">Laurent Eckert</name><affiliation wicri:level="1"><nlm:affiliation>Sanofi, Chilly-Mazarin, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sanofi, Chilly-Mazarin</wicri:regionArea><wicri:noRegion>Chilly-Mazarin</wicri:noRegion><wicri:noRegion>Chilly-Mazarin</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Nikhil" sort="Amin, Nikhil" uniqKey="Amin N" first="Nikhil" last="Amin">Nikhil Amin</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Graham, Neil M H" sort="Graham, Neil M H" uniqKey="Graham N" first="Neil M H" last="Graham">Neil M H. Graham</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Pirozzi, Gianluca" sort="Pirozzi, Gianluca" uniqKey="Pirozzi G" first="Gianluca" last="Pirozzi">Gianluca Pirozzi</name><affiliation wicri:level="2"><nlm:affiliation>Sanofi, Bridgewater, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sanofi, Bridgewater, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Stahl, Neil" sort="Stahl, Neil" uniqKey="Stahl N" first="Neil" last="Stahl">Neil Stahl</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Yancopoulos, George D" sort="Yancopoulos, George D" uniqKey="Yancopoulos G" first="George D" last="Yancopoulos">George D. Yancopoulos</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Shumel, Brad" sort="Shumel, Brad" uniqKey="Shumel B" first="Brad" last="Shumel">Brad Shumel</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28478972</idno><idno type="pmid">28478972</idno><idno type="doi">10.1016/S0140-6736(17)31191-1</idno><idno type="wicri:Area/PubMed/Corpus">000B38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B38</idno><idno type="wicri:Area/PubMed/Curation">000B35</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B35</idno><idno type="wicri:Area/PubMed/Checkpoint">000B35</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B35</idno><idno type="wicri:Area/Ncbi/Merge">004770</idno><idno type="wicri:Area/Ncbi/Curation">004770</idno><idno type="wicri:Area/Ncbi/Checkpoint">004770</idno><idno type="wicri:Area/Main/Merge">000874</idno><idno type="wicri:Area/Main/Curation">000879</idno><idno type="wicri:Area/Main/Exploration">000879</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial.</title><author><name sortKey="Blauvelt, Andrew" sort="Blauvelt, Andrew" uniqKey="Blauvelt A" first="Andrew" last="Blauvelt">Andrew Blauvelt</name><affiliation wicri:level="2"><nlm:affiliation>Oregon Medical Research Center, Portland, OR, USA. Electronic address: ablauvelt@oregonmedicalresearch.com.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oregon Medical Research Center, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="De Bruin Weller, Marjolein" sort="De Bruin Weller, Marjolein" uniqKey="De Bruin Weller M" first="Marjolein" last="De Bruin-Weller">Marjolein De Bruin-Weller</name><affiliation wicri:level="3"><nlm:affiliation>University Medical Center Utrecht, Utrecht, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Gooderham, Melinda" sort="Gooderham, Melinda" uniqKey="Gooderham M" first="Melinda" last="Gooderham">Melinda Gooderham</name><affiliation wicri:level="1"><nlm:affiliation>SKiN Centre for Dermatology, Queen's University, and Probity Medical Research, Peterborough, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>SKiN Centre for Dermatology, Queen's University, and Probity Medical Research, Peterborough, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Cather, Jennifer C" sort="Cather, Jennifer C" uniqKey="Cather J" first="Jennifer C" last="Cather">Jennifer C. Cather</name><affiliation wicri:level="2"><nlm:affiliation>Modern Dermatology and Modern Research Associates, and Probity Medical Research, Dallas, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Modern Dermatology and Modern Research Associates, and Probity Medical Research, Dallas, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Weisman, Jamie" sort="Weisman, Jamie" uniqKey="Weisman J" first="Jamie" last="Weisman">Jamie Weisman</name><affiliation wicri:level="2"><nlm:affiliation>Advanced Medical Research, PC, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Advanced Medical Research, PC, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Pariser, David" sort="Pariser, David" uniqKey="Pariser D" first="David" last="Pariser">David Pariser</name><affiliation wicri:level="2"><nlm:affiliation>Eastern Virginia Medical School and Virginia Clinical Research Inc, Norfolk, VA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Eastern Virginia Medical School and Virginia Clinical Research Inc, Norfolk, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Simpson, Eric L" sort="Simpson, Eric L" uniqKey="Simpson E" first="Eric L" last="Simpson">Eric L. Simpson</name><affiliation wicri:level="2"><nlm:affiliation>Oregon Health and Science University, Portland, OR, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Oregon Health and Science University, Portland, OR</wicri:regionArea><placeName><region type="state">Oregon</region></placeName></affiliation></author><author><name sortKey="Papp, Kim A" sort="Papp, Kim A" uniqKey="Papp K" first="Kim A" last="Papp">Kim A. Papp</name><affiliation wicri:level="1"><nlm:affiliation>K Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>K Papp Clinical Research and Probity Medical Research, Waterloo, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Hong, H Chih Ho" sort="Hong, H Chih Ho" uniqKey="Hong H" first="H Chih-Ho" last="Hong">H Chih-Ho Hong</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Skin Science, University of British Columbia, and Probity Medical Research, Surrey, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Dermatology and Skin Science, University of British Columbia, and Probity Medical Research, Surrey, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Rubel, Diana" sort="Rubel, Diana" uniqKey="Rubel D" first="Diana" last="Rubel">Diana Rubel</name><affiliation wicri:level="1"><nlm:affiliation>Australian National University, Canberra, and Probity Medical Research, Phillip, ACT, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Australian National University, Canberra, and Probity Medical Research, Phillip, ACT</wicri:regionArea><wicri:noRegion>ACT</wicri:noRegion></affiliation></author><author><name sortKey="Foley, Peter" sort="Foley, Peter" uniqKey="Foley P" first="Peter" last="Foley">Peter Foley</name><affiliation wicri:level="4"><nlm:affiliation>The University of Melbourne, Parkville, Skin & Cancer Foundation Inc, Carlton, and Probity Medical Research, Carlton, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>The University of Melbourne, Parkville, Skin & Cancer Foundation Inc, Carlton, and Probity Medical Research, Carlton, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Prens, Errol" sort="Prens, Errol" uniqKey="Prens E" first="Errol" last="Prens">Errol Prens</name><affiliation wicri:level="3"><nlm:affiliation>Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Erasmus University Medical Center Rotterdam, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Griffiths, Christopher E M" sort="Griffiths, Christopher E M" uniqKey="Griffiths C" first="Christopher E M" last="Griffiths">Christopher E M. Griffiths</name><affiliation wicri:level="4"><nlm:affiliation>The Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>The Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region><settlement type="city">Manchester</settlement></placeName><orgName type="university">Université de Manchester</orgName></affiliation></author><author><name sortKey="Etoh, Takafumi" sort="Etoh, Takafumi" uniqKey="Etoh T" first="Takafumi" last="Etoh">Takafumi Etoh</name><affiliation wicri:level="3"><nlm:affiliation>Tokyo Teishin Postal Services Agency Hospital, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Tokyo Teishin Postal Services Agency Hospital, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Pinto, Pedro Herranz" sort="Pinto, Pedro Herranz" uniqKey="Pinto P" first="Pedro Herranz" last="Pinto">Pedro Herranz Pinto</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, La Paz University Hospital, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Dermatology, La Paz University Hospital, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Pujol, Ramon M" sort="Pujol, Ramon M" uniqKey="Pujol R" first="Ramon M" last="Pujol">Ramon M. Pujol</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Hospital del Mar, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Dermatology, Hospital del Mar, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Szepietowski, Jacek C" sort="Szepietowski, Jacek C" uniqKey="Szepietowski J" first="Jacek C" last="Szepietowski">Jacek C. Szepietowski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, Venereology and Allergology, Wroclaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Dermatology, Venereology and Allergology, Wroclaw</wicri:regionArea><wicri:noRegion>Wroclaw</wicri:noRegion></affiliation></author><author><name sortKey="Ettler, Karel" sort="Ettler, Karel" uniqKey="Ettler K" first="Karel" last="Ettler">Karel Ettler</name><affiliation wicri:level="1"><nlm:affiliation>Dermatology and Venereology, Hradec Kralove, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Dermatology and Venereology, Hradec Kralove</wicri:regionArea><wicri:noRegion>Hradec Kralove</wicri:noRegion></affiliation></author><author><name sortKey="Kemeny, Lajos" sort="Kemeny, Lajos" uniqKey="Kemeny L" first="Lajos" last="Kemény">Lajos Kemény</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.</nlm:affiliation><country xml:lang="fr">Hongrie</country><wicri:regionArea>Department of Dermatology and Allergology, University of Szeged, Szeged</wicri:regionArea><wicri:noRegion>Szeged</wicri:noRegion></affiliation></author><author><name sortKey="Zhu, Xiaoping" sort="Zhu, Xiaoping" uniqKey="Zhu X" first="Xiaoping" last="Zhu">Xiaoping Zhu</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Basking Ridge, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Basking Ridge, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Akinlade, Bolanle" sort="Akinlade, Bolanle" uniqKey="Akinlade B" first="Bolanle" last="Akinlade">Bolanle Akinlade</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Hultsch, Thomas" sort="Hultsch, Thomas" uniqKey="Hultsch T" first="Thomas" last="Hultsch">Thomas Hultsch</name><affiliation wicri:level="2"><nlm:affiliation>Sanofi, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sanofi, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mastey, Vera" sort="Mastey, Vera" uniqKey="Mastey V" first="Vera" last="Mastey">Vera Mastey</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Gadkari, Abhijit" sort="Gadkari, Abhijit" uniqKey="Gadkari A" first="Abhijit" last="Gadkari">Abhijit Gadkari</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Eckert, Laurent" sort="Eckert, Laurent" uniqKey="Eckert L" first="Laurent" last="Eckert">Laurent Eckert</name><affiliation wicri:level="1"><nlm:affiliation>Sanofi, Chilly-Mazarin, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sanofi, Chilly-Mazarin</wicri:regionArea><wicri:noRegion>Chilly-Mazarin</wicri:noRegion><wicri:noRegion>Chilly-Mazarin</wicri:noRegion></affiliation></author><author><name sortKey="Amin, Nikhil" sort="Amin, Nikhil" uniqKey="Amin N" first="Nikhil" last="Amin">Nikhil Amin</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Graham, Neil M H" sort="Graham, Neil M H" uniqKey="Graham N" first="Neil M H" last="Graham">Neil M H. Graham</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Pirozzi, Gianluca" sort="Pirozzi, Gianluca" uniqKey="Pirozzi G" first="Gianluca" last="Pirozzi">Gianluca Pirozzi</name><affiliation wicri:level="2"><nlm:affiliation>Sanofi, Bridgewater, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Sanofi, Bridgewater, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Stahl, Neil" sort="Stahl, Neil" uniqKey="Stahl N" first="Neil" last="Stahl">Neil Stahl</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Yancopoulos, George D" sort="Yancopoulos, George D" uniqKey="Yancopoulos G" first="George D" last="Yancopoulos">George D. Yancopoulos</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Shumel, Brad" sort="Shumel, Brad" uniqKey="Shumel B" first="Brad" last="Shumel">Brad Shumel</name><affiliation wicri:level="2"><nlm:affiliation>Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Regeneron Pharmaceuticals Inc, Tarrytown, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Adult</term><term>Anti-Asthmatic Agents (therapeutic use)</term><term>Antibodies, Monoclonal (therapeutic use)</term><term>Dermatitis, Atopic (drug therapy)</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Male</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>United States</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Antiasthmatiques (usage thérapeutique)</term><term>Anticorps monoclonaux (usage thérapeutique)</term><term>Association de médicaments</term><term>Eczéma atopique (traitement médicamenteux)</term><term>Femelle</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains</term><term>Indice de gravité médicale</term><term>Injections sous-cutanées</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>États-Unis d'Amérique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Anti-Asthmatic Agents</term><term>Antibodies, Monoclonal</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dermatitis, Atopic</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Eczéma atopique</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiasthmatiques</term><term>Anticorps monoclonaux</term><term>Hormones corticosurrénaliennes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Double-Blind Method</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Male</term><term>Severity of Illness Index</term><term>Treatment Outcome</term><term>United States</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Association de médicaments</term><term>Femelle</term><term>Humains</term><term>Indice de gravité médicale</term><term>Injections sous-cutanées</term><term>Mâle</term><term>Méthode en double aveugle</term><term>Résultat thérapeutique</term><term>États-Unis d'Amérique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis. Previous 16-week monotherapy studies showed that dupilumab substantially improved signs and symptoms of moderate-to-severe atopic dermatitis with acceptable safety, validating the crucial role of interleukin 4 and interleukin 13 in atopic dermatitis pathogenesis. We aimed to evaluate the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical corticosteroids in adults with moderate-to-severe atopic dermatitis.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Hongrie</li><li>Japon</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>République tchèque</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Communauté de Madrid</li><li>Grand Manchester</li><li>Géorgie (États-Unis)</li><li>Hollande-Méridionale</li><li>Massachusetts</li><li>New Jersey</li><li>Oregon</li><li>Région de Kantō</li><li>Texas</li><li>Utrecht (province)</li><li>Victoria (État)</li><li>Virginie</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Madrid</li><li>Manchester</li><li>Melbourne</li><li>Rotterdam</li><li>Tokyo</li><li>Utrecht</li></settlement><orgName><li>Université de Manchester</li><li>Université de Melbourne</li></orgName></list><tree><country name="États-Unis"><region name="Oregon"><name sortKey="Blauvelt, Andrew" sort="Blauvelt, Andrew" uniqKey="Blauvelt A" first="Andrew" last="Blauvelt">Andrew Blauvelt</name></region><name sortKey="Akinlade, Bolanle" sort="Akinlade, Bolanle" uniqKey="Akinlade B" first="Bolanle" last="Akinlade">Bolanle Akinlade</name><name sortKey="Amin, Nikhil" sort="Amin, Nikhil" uniqKey="Amin N" first="Nikhil" last="Amin">Nikhil Amin</name><name sortKey="Cather, Jennifer C" sort="Cather, Jennifer C" uniqKey="Cather J" first="Jennifer C" last="Cather">Jennifer C. Cather</name><name sortKey="Gadkari, Abhijit" sort="Gadkari, Abhijit" uniqKey="Gadkari A" first="Abhijit" last="Gadkari">Abhijit Gadkari</name><name sortKey="Graham, Neil M H" sort="Graham, Neil M H" uniqKey="Graham N" first="Neil M H" last="Graham">Neil M H. Graham</name><name sortKey="Hultsch, Thomas" sort="Hultsch, Thomas" uniqKey="Hultsch T" first="Thomas" last="Hultsch">Thomas Hultsch</name><name sortKey="Mastey, Vera" sort="Mastey, Vera" uniqKey="Mastey V" first="Vera" last="Mastey">Vera Mastey</name><name sortKey="Pariser, David" sort="Pariser, David" uniqKey="Pariser D" first="David" last="Pariser">David Pariser</name><name sortKey="Pirozzi, Gianluca" sort="Pirozzi, Gianluca" uniqKey="Pirozzi G" first="Gianluca" last="Pirozzi">Gianluca Pirozzi</name><name sortKey="Shumel, Brad" sort="Shumel, Brad" uniqKey="Shumel B" first="Brad" last="Shumel">Brad Shumel</name><name sortKey="Simpson, Eric L" sort="Simpson, Eric L" uniqKey="Simpson E" first="Eric L" last="Simpson">Eric L. Simpson</name><name sortKey="Stahl, Neil" sort="Stahl, Neil" uniqKey="Stahl N" first="Neil" last="Stahl">Neil Stahl</name><name sortKey="Weisman, Jamie" sort="Weisman, Jamie" uniqKey="Weisman J" first="Jamie" last="Weisman">Jamie Weisman</name><name sortKey="Yancopoulos, George D" sort="Yancopoulos, George D" uniqKey="Yancopoulos G" first="George D" last="Yancopoulos">George D. Yancopoulos</name><name sortKey="Zhu, Xiaoping" sort="Zhu, Xiaoping" uniqKey="Zhu X" first="Xiaoping" last="Zhu">Xiaoping Zhu</name></country><country name="Pays-Bas"><region name="Utrecht (province)"><name sortKey="De Bruin Weller, Marjolein" sort="De Bruin Weller, Marjolein" uniqKey="De Bruin Weller M" first="Marjolein" last="De Bruin-Weller">Marjolein De Bruin-Weller</name></region><name sortKey="Prens, Errol" sort="Prens, Errol" uniqKey="Prens E" first="Errol" last="Prens">Errol Prens</name></country><country name="Canada"><noRegion><name sortKey="Gooderham, Melinda" sort="Gooderham, Melinda" uniqKey="Gooderham M" first="Melinda" last="Gooderham">Melinda Gooderham</name></noRegion><name sortKey="Hong, H Chih Ho" sort="Hong, H Chih Ho" uniqKey="Hong H" first="H Chih-Ho" last="Hong">H Chih-Ho Hong</name><name sortKey="Papp, Kim A" sort="Papp, Kim A" uniqKey="Papp K" first="Kim A" last="Papp">Kim A. Papp</name></country><country name="Australie"><noRegion><name sortKey="Rubel, Diana" sort="Rubel, Diana" uniqKey="Rubel D" first="Diana" last="Rubel">Diana Rubel</name></noRegion><name sortKey="Foley, Peter" sort="Foley, Peter" uniqKey="Foley P" first="Peter" last="Foley">Peter Foley</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Griffiths, Christopher E M" sort="Griffiths, Christopher E M" uniqKey="Griffiths C" first="Christopher E M" last="Griffiths">Christopher E M. Griffiths</name></region></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Etoh, Takafumi" sort="Etoh, Takafumi" uniqKey="Etoh T" first="Takafumi" last="Etoh">Takafumi Etoh</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Pinto, Pedro Herranz" sort="Pinto, Pedro Herranz" uniqKey="Pinto P" first="Pedro Herranz" last="Pinto">Pedro Herranz Pinto</name></region><name sortKey="Pujol, Ramon M" sort="Pujol, Ramon M" uniqKey="Pujol R" first="Ramon M" last="Pujol">Ramon M. Pujol</name></country><country name="Pologne"><noRegion><name sortKey="Szepietowski, Jacek C" sort="Szepietowski, Jacek C" uniqKey="Szepietowski J" first="Jacek C" last="Szepietowski">Jacek C. Szepietowski</name></noRegion></country><country name="République tchèque"><noRegion><name sortKey="Ettler, Karel" sort="Ettler, Karel" uniqKey="Ettler K" first="Karel" last="Ettler">Karel Ettler</name></noRegion></country><country name="Hongrie"><noRegion><name sortKey="Kemeny, Lajos" sort="Kemeny, Lajos" uniqKey="Kemeny L" first="Lajos" last="Kemény">Lajos Kemény</name></noRegion></country><country name="France"><noRegion><name sortKey="Eckert, Laurent" sort="Eckert, Laurent" uniqKey="Eckert L" first="Laurent" last="Eckert">Laurent Eckert</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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